New generation of drugs protecting against neurotoxic industrial chemicals (NeuroTICs)

Human brain is a great target for chemical terrorism, so NATO nations should be prepared to respond effectively to terrorist threats involving neurotoxic industrial chemicals (neuroTICs). The main objective of this project is to assess the therapeutic potential of AD4 and thioredoxin-mimetic peptides, blood-brain barrier permeable drugs targeting oxidative stress, apoptosis and inflammation, on acute neurotoxic syndromes induced by three common TICs (organophosphorus compounds, acrylamide, organic mercury). Moreover, specific combinations of drugs derived from the analysis of potential therapeutic targets for each toxidrome will be also tested.

Science for Peace and Security (SPS) Programme
Multi-Year Project SPS.MYP G5852